Nevus sebaceus of Jadassohn is a congenital cutaneous hamartoma comprised of multiple skin structures. It has the potential to develop into variety of neoplasms of various epidermal adnexal origins. While multiple tumors may occasionally arise, it is unusual for more than four tumors to arise simultaneously within a single sebaceus nevus. Here in, we report a case of a 70-year-old woman with six neoplastic proliferations including a syringocystadenoma papilliferum, pigmented trichoblastoma, tubular apocrine adenoma, sebaceoma, tumors of follicular infundibulum and superficial epithelioma with sebaceus differentiation arising in a long standing nevus sebaceus on the scalp. Our case is extraordinary because a single nevus sebaceus contained six neoplastic proliferations with differentiation toward the folliculosebaceous-apocrine unit.

Citations

Citations to this article as recorded by  

• Tumor of follicular infundibulum – reappraisal in a series of 28 patients with critical review of the literature
  Michael Wilk, Bettina G. Zelger, Bernhard Zelger
  JDDG: Journal der Deutschen Dermatologischen Gesellschaft.2024; 22(2): 223.     CrossRef
• Tumor des follikulären Infundibulums – Neubewertung in einer Serie von 28 Patienten mit kritischer Analyse der Literatur
  Michael Wilk, Bettina G. Zelger, Bernhard Zelger
  JDDG: Journal der Deutschen Dermatologischen Gesellschaft.2024; 22(2): 223.     CrossRef
• Adnexal neoplasms of the eye
  Roman Drozdowski, Jane M. Grant-Kels, Madina Falcone, Campbell L. Stewart
  Clinics in Dermatology.2024;[Epub]     CrossRef
• Melanotrichoblastoma: sixth case report in the literature
  Juliana Polizel Ocanha-Xavier, José Cândido Caldeira Xavier-Júnior
  Anais Brasileiros de Dermatologia.2023; 98(6): 871.     CrossRef
• Multiple secondary neoplasms in nevus sebaceus excision
  Travis S. Dowdle, David A. Mehegran, Dylan Maldonado, Cort D. McCaughey
  Baylor University Medical Center Proceedings.2022; 35(2): 241.     CrossRef
• Congenital tumors arising from nevus sebaceous in 2 neonates
  Lynette Wei Yi Wee, Bori Born, Sharon Mun Yee Wong, Hui-Ling Chia, Sithach Mey, Suresh Chandran, Mark Jean Aan Koh
  JAAD Case Reports.2022; 21: 70.     CrossRef
• Development of seven secondary neoplasms in a nevus sebaceous: a case report and literature review
  Yi-Wen Kuo, Jung-Chia Lin, Wei-Hsuan Tsai
  Archives of Craniofacial Surgery.2022; 23(2): 83.     CrossRef
• Multiple rare neoplasms arising from the nevus sebaceous of the scalp: A case report
  Deepthi Shetty, Anilkumar Desai, Niranjan Kumar, Dinesh U.S., Aditya Agnihotri, Saurav Bhaduri
  Gulhane Medical Journal.2022; 64(2): 197.     CrossRef
• Syringocystadenoma Papilliferum and Basal Cell Carcinoma Arising in Nevus Sebaceous
  Jingjing Jiang, Yujuan Chen, Qi He, Jiao Yang, Zhengzhong Zhang, Hao Yang, Huan Zhang, Chuan Yang
  Clinical, Cosmetic and Investigational Dermatology.2022; Volume 15: 2021.     CrossRef
• Eyelid trichoblastoma – A case series
  Gunja Chowdhury, Meghana Tanwar, Usha Kim, ShanthiR Krishnan
  Journal of Clinical Ophthalmology and Research.2021; 9(3): 123.     CrossRef
• Trilogy revisited: A case report of co-sexisting nevus sebaceous with syringocystadenoma papilliferum and tubular apocrine adenoma
  Anand Bardia, Debajyoti Chatterjee, Keshavamurthy Vinay
  Indian Dermatology Online Journal.2021; 12(4): 577.     CrossRef
• Trichilemmoma coexisting with sebaceous nevus
  AngooriG Rao, VangaliS Reddy, M Tejal, M Divya
  Indian Dermatology Online Journal.2020; 11(2): 253.     CrossRef
• Syndromic sebaceous nevus: current findings
  Oumama El Ezzi, Anthony S. de Buys Roessingh, Michèle Bigorre, Guillaume Captier
  International Journal of Dermatology.2018; 57(5): 599.     CrossRef
• Syringocystadenoma papilliferum and trichoblastoma arising in the nevus sebaceous
  Feifei Wang, Yatong Wu, Zhancai Zheng, Yanping Bai
  Indian Journal of Pathology and Microbiology.2018; 61(1): 106.     CrossRef
• Dermoscopic Analysis of Nevus Sebaceus of Jadassohn: A Study of 13 Cases
  Awatef Kelati, Hanane Baybay, Salim Gallouj, Fatima Zahra Mernissi
  Skin Appendage Disorders.2017; 3(2): 83.     CrossRef
• Secondary neoplasms arising from nevus sebaceus: A retrospective study of 450 cases in Taiwan
  Ming‐Chun Hsu, Jau‐Yu Liau, Jin‐Liern Hong, Yin Cheng, Yi‐Hua Liao, Jau‐Shiuh Chen, Yi‐Shuan Sheen, Jin‐Bon Hong
  The Journal of Dermatology.2016; 43(2): 175.     CrossRef
• A Histological Snapshot of Hypothetical Multistep Progression From Nevus Sebaceus to Invasive Syringocystadenocarcinoma Papilliferum
  Vishwas Parekh, Cesar E. Guerrero, Charles F. Knapp, Craig A. Elmets, Kristopher M. McKay
  The American Journal of Dermatopathology.2016; 38(1): 56.     CrossRef
• Trichoblastoma, syringocystadenoma papilliferum, desmoplastic trichilemmoma and tumor of the follicular infundibulum with signet‐ring cells, all arising in nevus sebaceus
  Emilie Dore, Megan H. Noe, Brian L. Swick
  Journal of Cutaneous Pathology.2015; 42(9): 645.     CrossRef
• Ceruminous adenoma (ceruminoma) arising in a nevus sebaceus of Jadassohn within the external auditory canal of a 3 year-old boy – A case report
  Elżbieta Niemczyk, Kazimierz Niemczyk, Jadwiga Małdyk, Lidia Zawadzka-Głos
  International Journal of Pediatric Otorhinolaryngology.2015; 79(11): 1932.     CrossRef
• Fehlbildungen und Nävi des behaarten Kopfes
  V. Behle, H. Hamm
  Der Hautarzt.2014; 65(12): 1022.     CrossRef